Insulin is a hormone secreted by the pancreas that enables glucose, which comes from the food you eat, in the blood to enter in cells of your muscles, fats, and liver, where it is utilized for energy. Glucose. The liver additionally creates glucose in hours of need, for instance when you are fasting. Blood glucose, also known as blood sugar, levels ascend after you eat as your pancreas releases insulin hormone into the blood. Insulin then brings blood glucose down to keep it in the normal ranges.

What is Insulin Resistance?

Insulin acts as a key that permits the access of glucose to cells. If glucose can’t get inside the cells, it backlogs in the blood and this can result in damage to your organs.

The minute when the organism quits responding to insulin is termed as insulin resistance or low insulin sensitivity. However, more technically, it is also known as hyper-insulinemia.

This variation is created in the adipose tissue that makes it difficult for insulin to perform its function. Insulin produced by the pancreas does not work in a normal way, so the body does not respond as it should. Along these lines, glycemia increases and the pancreas continues increasing the requirement of more insulin.

Insulin resistance happens at that time cells in muscles, fat, and liver does not react well to insulin and can only with significant effort take up glucose from your blood. Consequently, your pancreas makes more insulin to assist glucose in entering your cells. On condition that your pancreas can secrete enough insulin to overcome your nonresponsive state of cells to insulin, your blood glucose levels will remain in a healthy range.

Insulin Resistance and Prediabetes

Prediabetes implies your blood glucose levels are elevated than normal yet not sufficiently high to be diagnosed as diabetes. Prediabetes typically happens in individuals who already have some insulin resistance or else whose beta cells of the pancreas are not making an adequate amount of insulin to keep blood glucose within the normal range. Without enough insulin, extra glucose remains in your bloodstream instead of getting entered in your cells. After some time, type 2 diabetes becomes developed.

Over and above 84 million persons of ages 18 and older are suffering from prediabetes in the United States, which makes about 1 out of every 3 adults.

One in every three Americans, comprising 50 percent of those who are 60 years and older in age, have a silent blood sugar issue called insulin resistance. Insulin resistance upturns the risk for prediabetes, type 2 diabetes and a multitude of additional serious medical issues together with heart attacks, strokes, and cancer.

Who is more likely to Develop Insulin Resistance?

Individuals who have hereditary or lifestyle risk factors are more on the verge of developing insulin resistance or prediabetes.

The major risk factors include:

  • Being overweight or obese
  • Of age 45 or older
  • Having a parent, or siblings with diabetes
  • Belonging to the ethnicity of African American, Alaska Native, American Indian, Asian American, Hispanic/Latino, Native Hawaiian, Pacific Islander American
  • Physically inactive
  • Being hypertensive or high blood pressure
  • Having high levels of cholesterol and bad lipids
  • A history of diabetes during pregnancy or gestational diabetes
  • A history of cardiac disease or stroke
  • Polycystic ovary syndrome, also known as PCOS in females
  • Individuals having metabolic syndrome, which implies a combination of high blood pressure, abnormal cholesterol levels, and large waist size, are more likely to have prediabetes
  • In conjunction with these risk factors, different things that may add to insulin resistance includes:
  • Certain medications, for example, glucocorticoids, some antipsychotics and some meds for
  • Hormonal imbalances, for example, Cushing’s syndrome and acromegaly
  • Sleep issues, particularly sleep apnea or cessation of breath during sleep

In spite of the fact that you can’t alter the risk factors of family history, age or ethnicity, you can modify your risk factors of the way of life, eating habits, physical activity, and body weight. These lifestyle modifications can bring down your odds of developing insulin resistance or prediabetes.

Causes of Insulin Resistance

While the accurate reason for insulin resistance is as yet not completely understood, it is notable which elements can set in motion the development of insulin resistance.

Insulin resistance can develop commonly if at least one of the following factors which are somehow related to the risk factors are fulfilled.

  • If you are overweight or obese
  • Having a fatty or high-calorie diet, high carbohydrate or high sugar diet
  • Sedentary lifestyle implying minimal physical activity
  • Taking high dosages of steroids over a long period of time
  • Complaints of chronic stress
  • Having Cushing’s disease
  • Polycystic ovary disease

Regarding what is going on within the body that develops insulin resistance, researchers have seen that insulin resistance takes place in individuals that have:

  • Elevated levels of insulin flowing in their blood
  • Excessive fat packed up in the liver as well as pancreas
  • Elevated levels of inflammation within the body

How Insulin Resistance Develops

Even though genetics, aging, and ethnicity take part in building insulin sensitivity, the main impetuses behind insulin resistance consist of excessive body weight, an excess of tummy fat, an absence of exercise in daily routine, smoking and even holding back on sleep.

As insulin resistance builds up, your body responds back by secreting more insulin. Over months and years, the beta cells of the pancreas that are functioning so hard to produce insulin get dead beat and can never keep pace again with the demand for ever more insulin. Subsequently, years after insulin resistance quietly began, your blood glucose may start to rise and you may perhaps develop prediabetes or type 2 diabetes. You might likewise develop the non-alcoholic fatty liver disease (NAFLD), a progressively growing problem related to insulin resistance that lifts your possibility for liver damage and cardiac disease.

How does insulin resistance become diabetes?

In an individual with prediabetes, the pancreas strives to discharge enough insulin to combat the body’s resistance and keep blood glucose levels at a minimum.
After some time, the pancreas’ capacity to release insulin starts to diminish, which brings about the development of diabetes type 2. Insulin resistance stays a significant component of type 2 diabetes.

Symptoms of Insulin Resistance

The insulin resistance is not taken as a disease, therefore its symptoms are harder to characterize clinically. On the other hand, there is a series of indications that can give an idea of this problem:

  • Voiding syndrome which includes frequent urge to urinate
  • Polydipsia, a condition in which there is an excessive and urgent need to drink
  • Anxiety for food, particularly sugar or carbohydrates
  • Generalized body fatigue when muscles do not get enough energy to work appropriately
  • Weight gain, mainly mounting up fat in the abdominal or belly zone
  • Hyperpigmentation which is the darkening of certain parts of the body, principally neck, areas of the axilla and the groin
  • Cardiovascular issues that account for hypertension, imbalances in lipid levels (hypercholesterolemia or hypertriglyceridemia), pre-diabetes or diabetes

How to Diagnosis Insulin Resistance?

Various tests can help to diagnose prediabetes and diabetes, some of the major ones include:

HBA1C Test

This measures an individual’s average glucose levels in the blood over the past 2 to 3 months. Values of 5.7 to 6.4 percent show prediabetes.

Fasting Blood Glucose Test

The glucose levels are checked after a person avoids eating or drinking for at least 8 hours or more. The test result value of 100 to 125 mg/dL (milligrams per deciliter) indicates prediabetes.

Random Glucose Test

This implicates checking the blood glucose levels sooner or later during the day or at any time of the day. A test value of 140 mg/dL or more indicates prediabetes.

Usually, more than one of the above tests is requested to perform to make sure the levels and reach an exact diagnosis.

If blood glucose levels constantly fall outside of the normal ranges, it may indicate that the body is getting resistant to insulin.

Obesity and Insulin Resistance

Almost 40 % of the U.S. residents now go through from obesity and 45 % suffer from ill effects of either prediabetes or type 2 diabetes. There is a significant overlap among these diseases, with over 85 % of patients diagnosed to have type 2 diabetes additionally suffer from overweight or obesity.

What does insulin resistance have to do with obesity?

Well before type 2 diabetes and even prediabetes is diagnosed, insulin resistance is previously creeping up. Obesity and insulin resistance are linked in a number of ways. Contingent upon the diagnostic criteria, this figure may ascend to 44 percent in females with obesity and over 80 percent in several patient groups.

Around 33 % of kids and teenagers with obesity might have insulin resistance equally and the adverse impacts of excessive adiposity on insulin-mediated glucose uptake (IMGU) are well-perceived among them. Metabolic abnormalities related to obesity were identified with changes in the size of the fat cells instead of a number, the bigger the fat cell, the more reduced reaction to insulin is recognized.

The connection between obesity and insulin resistance (IR) has concentrated on differences in the regional distribution of fat. In general, it has been reasoned that abdominal obesity, especially an expansion in visceral fat volume, is the key culprit being responsible for insulin resistance and related abnormalities.

Mechanistically, it has been suggested that large visceral fat cells release a number of inflammatory cytokines that result in IR. In this way, enlargement of fat cells turns out to be a source of circulating inflammatory markers that have converged to make one hypothesis representing the connection obesity and insulin resistance.

How to Reverse Insulin Resistance?

In the event that you have insulin resistance, you need to convert it into the inverse that is to become more insulin sensitive (the opposite of insulin resistance or low insulin sensitivity). Try incorporating the following habits in your lifestyle and see the changes.

Physical Activity

Physical activity is one of the ways that make you progressively sensitive to insulin, one motive why it is a keystone of diabetes management and better health by and large. Try not to hold up until you are diagnosed with diabetes to begin physical activity. The earlier you make a move, you will be at an advantage in a real way.

Weight Loss

Weight loss is significant as well, as is staying away from high glucose, decreasing stress and taking enough sleep.

It is beyond the realm of imagination to impact some risk factors for insulin resistance or type 2 diabetes, like family history or genetic makeup.

However, an individual can find a way to decrease the odds of turning out to be insulin resistant. These ways of life change truly work.

Moreover, the American Heart Association (AHA) report shows that a person can reduce the danger of type 2 diabetes by creating preventive changes in way of life, first and foremost by shedding pounds and by increasing physical activity.

Muscles become increasingly sensitive to insulin after the spell of exercise and an individual can switch insulin resistance with an active or refreshing lifestyle.

Despite the fact that the diagnosis of insulin resistance or prediabetes might bring an alarming situation, making quick lifestyle changes and expecting instantaneous outcomes is certifiably not a practical approach.

Rather, increase your levels of physical activity in a gradual way, replace one thing for every supper with a healthful, low carbohydrate option and make certain to keep this up without getting fail.

The highly effective approach to decrease insulin resistance is to make moderate and sustainable changes.

Stop Smoking

Tobacco smoking can lead to insulin resistance, so quitting should support in avoiding IR.

Reduce Sugar Consumption

Take a step to reduce your intake of refined sugars, particularly from sugar-sweetened drinks.

Eat Healthy Food

Take a diet based frequently, on the whole, unprocessed and natural foods. Add nuts as well as fatty fish ion your dietary regime. Take Omega-3 fatty acids as they may decrease insulin resistance and lower level of blood triglycerides.

An insulin resistance meal plan must include vegetables and a source of lean protein in most meals and snacks. It must have plenty of whole grains, fat-free dairy products, and healthy fats. You can consider a large portion of your plate with vegetables at most meals, and adding a good serving of lean protein.

Use Supplements

Berberine may improve insulin sensitivity and decrease blood sugar. Magnesium supplements may well be useful too.

Take Proper Sleep

Evidence recommends that poor sleep causes insulin resistance, so refining sleep quality might help.

Reduce Stress

Try to deal with your feelings of anxiety and stress if you easily get a victim of it. Staying happy and positive will help you more in decreasing IR.


Insulin resistance might be one of the main drivers of many of today’s chronic diseases.

However, you can improve this condition with a basic way of life measures. Preventing insulin resistance might be among the most dominant approaches to carry on with a more drawn out and healthier life.

Prediabetes is just a warning. Research shows that changes in your way of life can lessen the danger of prediabetes progression to diabetes by more than 58 percent.

Converse with your health care provider regarding exactly how to begin and start making strides today to reduce insulin resistance and the risks of developing diabetes.